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Individual laboratories are equipped with modern instrumentation for biophysical investigations.  The resources include X-ray diffractiometers for the determination of three-dimensional structure of biomolecules, microcalorimetry equipment for thermodynamic analyses of proteins and their affinity for other molecules, state-of-the-art fluorescence and circular dichroism spectrophotometers for characterizing protein and nucleic acid folding, and advanced computing power for database analysis and various structural and dyynamic calculations.

In addition, multiple facilities are available to PMB participants through the Johns Hopkins University and Medical Institutions.

Center for Molecular Biophysics

CMB provides the resources and intellectual environment to facilitate biophysical research, both for biophysically-oriented laboratories, and for those laboratories whose research has not traditionally involved structural or biophysical characterization.

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Mass Spectrometry

Accurate mass measurements for small and large molecules can be obtained at the Mass Spectrometry Facility of the Chemistry Department and the Proteomics Facility of the Institute for Basic Biomedical Sciences.

X-ray crystallography facility

JHU Homewood X-ray Crystallography Facility

A structural analysis center in the New Chemistry Building on the Homewood campus.

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Biological NMR

State-of-the-art solution state NMR equipment is available at the Biomolecular NMR Center on the Homewood campus and at the School of Medicine NMR Facility.  The instruments include 500, 600, and 800 MHz-NMR spectrometers.  In-depth training is provided by Dr. Ananya Majumdar, Director of the Center.

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X-ray Crystallography

Located in the Department of Biophysics & Biophysical Chemistry at the Medical School, this facility is fully equipped with several X-ray generators, detectors, and computers.  It is maintained as a departmental facility and staffed by a full-time manager.

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Synthesis and Sequencing

Protein and nucleic acids can be made or analyzed with excellent turn-around time at the Synthesis and Sequencing Facility of the Medical School.

Also available to the Hopkins community:

Malaria Research Institute Biophysics Core logo

Malarai Research Institute Biophysics Core Facility

Instrumentation for characterization of macromolecules or macromolecular complexes using biophysical techniques (isothermal titration calorimetry, dynamic light scattering, circular dichroism and X-ray crystallography).

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Integrated Imaging Center

Instrumentation necessary for basic and advanced light and electron microscopy (LM/EM), including 3-D and 4-D imaging, FRET, FRAP,  and FCS among others.

ChemCore logo


Compound repository and high throughput robotics laboratory services for enzymatic and biologic assays.

High Throughput Biology Center logo

High Throughput Biology Center

For the study of interactions of chemical compounds, gene products, cells and organisms and the networks formed by these interactions.

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Flow Cytometry Core Analytic Laboratories

For the characterization and separation of particles as diverse as beads, cells and chromosomes.

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Microscope Facility

For light and electron microscopy and electronic imaging.

Additional resources:

Department of Chemistry, Arts & Sciences
The Chemistry Department has a wide array of instrumentation in addition to the NMR and spectroscopy facilities mentioned above.

Institute for Basic Biomedical Sciences Technology Hubs, Medicine
In addition to those listed above are the Genetic Resources Core Facility, Microarray Facility, Middle Atlantic Mass Spectrometry Laboratory, and Protein/Peptide Sequencing Facility.

Johns Hopkins Malaria Institute Core Facilities, Public Health
In addition to the Biophysics Core facility, the Institute has an Imaging and Microscopy Core, and a Gene Array Core.

Program in Molecular Biophysics
101 Jenkins Hall
3400 N. Charles Street
Baltimore, MD 21218

410-516-5197 phone
410-516-5199 fax


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