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PMB Faculty Research

Amzel scientific image

Mario Amzel
Professor and Director, Biophysics & Biophysical Chemistry
Structure and mechanism of proteins involved in redox or phosphoryl transfer reactions, such as FPPS, MICAL, and Pl3K-alpha.  Many of these proteins studied are targets for drug design.

Scott Bailey scientific image

Scott Bailey
Assistant Professor, Biochemistry & Molecular Biology
Structural and functional studies of protein-nucleic acid interaction

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Doug Barrick
Professor, Biophysics
Stability and folding of modular proteins, structure and sequence analysis of protein evolution, protein-protein interactions in signaling pathways

James Berger
Professor, Biophysics & Biophysical Chemistry
Structural and mechanistic biochemistry of protein/nucleic acid machines and assemblies

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Greg Bowman
Associate Professor, Biophysics
Structural biology of molecular machines that remodel nucleosomes

Chirikjian scientific image

Greg Chirikjian
Professor, Mechanical Engineering
Computational mechanics of large proteins, conformational statistics of biological macromolecules, applied mathematics

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Phil Cole
Professor, Pharmacology & Molecular Sciences
Chemical and biochemical approaches to signal transduction

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Richard Cone
Professor, Biophysics
Mucosal protection by bacteria

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Karen Fleming
Professor, Biophysics
Membrane protein folding, cellular biogenesis of membrane proteins, thermodynamics of protein-protein interactions in membranes, protein engineering, membrane protein modeling

Dominique Frueh scientific imageDominique Frueh
Assistant Professor, Biophysics & Biophysical Chemistry
NMR studies of the modulations of protein dynamics and conformations in active enzymatic systems
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Bertrand García-Moreno
Professor and Chair, Biophysics
Experimental and computational studies of protein electrostatics, pH dependent processesin biology, biological energy transduction, protein design and evolution

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Jeffrey Gray
Associate Professor, Chemical & Biomolecular Engineering
Biomolecular modeling, protein-protein docking, protein-surface interactions, allostery, biomineralization

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Rachel Green
Professor, Molecular Biology & Genetics
Molecular mechanisms of translation and its regulation

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Marc Greenberg
Professor, Chemistry
Studies on DNA damage and repair, and their applications 

Taekjip Ha
Professor, Biophysics & Biophysical Chemistry, Biophysics, and Biomedical Engineering
Single-molecule studies of genomic maintenance

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Vincent J. Hilser
Professor and Chair, Biology
Conformational fluctuations in function, disease and evolution

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Kalina Hristova
Professor, Materials Science & Engineering
Cell membrane biophysics, signal transduction, receptor tyrosine kinases, molecular basis of disease, protein-lipid interactions, membrane protein folding, supported bilayers

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Margaret Johnson
Assistant Professor, Biophysics
Theoretical and computational modeling of protein interactions at the cellular scale

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Christian Kaiser
Assistant Professor, Biology
Single-molecule studies of the machines and processes in protein translation, translocation and folding

Lau scientific imageAlbert Lau
Assistant Professor, Biophysics & Biophysical Chemistry
Characterization of biomolecular association and conformational transitions using computational and crystallographic approaches
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Juliette Lecomte
Professor & Program Director, Biophysics
Structure and dynamics of proteins in solution by NMR spectroscopy

Sua Myong
Associate Professor, Biophysics
Single molecule and single cell imaging to investigate regulations in gene expression

Ostermeier scientific image

Marc Ostermeier
Professor, Chemical & Biomolecular Engineering
Biomolecular engineering

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Sean Prigge
Associate Professor, Molecular Microbiology & Immunology
Crystallography of malaria proteins

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Elijah Roberts
Assistant Professor, Biophysics
Investigating the creation and use of in silico cell models

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Steven Rokita
Professor, Chemistry
Mechanistic and structural studies of enzymes, reversible but covalent reactivity of nucleic acids

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Justine Roth
Associate Professor, Chemistry
Metalloenzyme catalysis, mechanistic studies of oxidative protein modification and damage by reactive oxygen species

Sadegh-Nasseri scientific image

Scheherazade Sadegh-Nasseri
Professor, Pathology
Mechanisms of T cell activation and unresponsiveness, mechanisms of antigen processing and presentation

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Joel Schildbach
Professor, Biology
Structural, biochemical, and functional studies of proteins involved in DNA transfer by bacterial conjugation

Schleif scientific imageRobert Schleif
Professor, Biology
Mechanism of protein function, particularly regulatory proteins, using genetic, biochemical, biophysical, and computational methods
Shortle scientific imageDavid Shortle
Professor, Biological Chemistry
Protein folding and stability, NMR analysis of denatured protein, prediction of protein structure from sequence
Jungsan Sohn research image

Jungsan Sohn
Assistant Professor, Biophysics & Biophysical Chemistry
Structure and function of biological stress-sensors

Stivers scientific imageJim Stivers
Professor, Pharmacology & Molecular Sciences
Enzymology of DNA repair and topoisomerases, structure and mechanism by NMR spectroscopy, inhibitor design
Tolman scientific imageJoel Tolman
Associate Professor, Chemistry
Experimental and theoretical NMR, protein structure and function, polyubiquitylation
Townsend scientific imageCraig Townsend
Professor, Chemistry
Natural product chemistry, enzymology and molecular biology, fatty acid synthase inhibitors for cancer, tuberculosis and obesity
Wade scientific imageHerschel Wade
Assistant Professor, Biophysics & Biophysical Chemistry
Molecular mechanisms of ligand-dependent transcriptional activation-repression, broadly-specific receptor-ligand systems
Wolberger scientific imageCynthia Wolberger
Professor, Biophysics & Biophysical Chemistry
Structural and mechanistic studies of transcription regulation and ubiquitin signaling
Woodson scientific imageSarah Woodson
Professor, Biophysics
Folding and dynamics of RNA and RNA-protein complexes
Jie Xiao research imageJie Xiao
Associate Professor, Biophysics & Biophysical Chemistry
Molecular mechanisms of transcription and cytokinesis in bacterial cells

Program in Molecular Biophysics
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