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PMB Faculty Research
 

Amzel scientific image

Mario Amzel
Professor and Director, Biophysics & Biophysical Chemistry
Structure and mechanism of proteins involved in redox or phosphoryl transfer reactions, such as FPPS, MICAL, and Pl3K-alpha.  Many of these proteins studied are targets for drug design.

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Scott Bailey
Assistant Professor, Biochemistry & Molecular Biology
Structural and functional studies of protein-nucleic acid interaction

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Doug Barrick
Professor, Biophysics
Stability and folding of modular proteins, structure and sequence analysis of protein evolution, protein-protein interactions in signaling pathways

James Berger
Professor, Biophysics & Biophysical Chemistry
Structural and mechanistic biochemistry of protein/nucleic acid machines and assemblies

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Jürgen Bosch
Assistant Professor, Biochemistry & Molecular Biology
Structural biology of macromolecular complexes critical for malaria pathogenicity, structure-based drug design

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Greg Bowman
Associate Professor, Biophysics
Structural biology of molecular machines that remodel nucleosomes

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Greg Chirikjian
Professor, Mechanical Engineering
Computational mechanics of large proteins, conformational statistics of biological macromolecules, applied mathematics

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Phil Cole
Professor, Pharmacology & Molecular Sciences
Chemical and biochemical approaches to signal transduction

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Richard Cone
Professor, Biophysics
Mucosal protection by bacteria

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Karen Fleming
Professor, Biophysics
Membrane protein folding, thermodynamics of protein-protein interactions in membranes, protein engineering, membrane protein modeling

Dominique Frueh scientific imageDominique Frueh
Assistant Professor, Biophysics & Biophysical Chemistry
NMR studies of the modulations of protein dynamics and conformations in active enzymatic systems
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Bertrand García-Moreno
Professor and Chair, Biophysics
Experimental and computational studies of protein electrostatics, pH dependent processesin biology, biological energy transduction, protein design and evolution

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Jeffrey Gray
Associate Professor, Chemical & Biomolecular Engineering
Biomolecular modeling, protein-protein docking, protein-surface interactions, allostery, biomineralization

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Rachel Green
Professor, Molecular Biology & Genetics
Molecular mechanisms of translation and its regulation

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Marc Greenberg
Professor, Chemistry
Studies on DNA damage and repair, and their applications 

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Vincent J. Hilser
Professor, Biology
Conformational fluctuations in function, disease and evolution

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Jan Hoh
Associate Professor, Physiology
Biophysical interactions between biological macromolecules and macromolecular complexes, development of new technology and biomedical applications for scanned probe microscopes

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Kalina Hristova
Professor, Materials Science & Engineering
Cell membrane biophysics, signal transduction, receptor tyrosine kinases, molecular basis of disease, protein-lipid interactions, membrane protein folding, supported bilayers

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Margaret Johnson
Assistant Professor, Biophysics
Theoretical and computational modeling of protein interactions at the cellular scale

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Christian Kaiser
Assistant Professor, Biology
Single-molecule studies of the machines and processes in protein translation, translocation and folding

Lau scientific imageAlbert Lau
Assistant Professor, Biophysics & Biophysical Chemistry
Characterization of biomolecular association and conformational transitions using computational and crystallographic approaches
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Dan Leahy
Professor, Biophysics & Biophysical Chemistry
Structural and biophysical characterization of signaling pathways

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Juliette Lecomte
Professor & Program Director, Biophysics
Structure and dynamics of proteins in solution by NMR spectroscopy

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Paul Miller
Professor, Biochemistry & Molecular Biology
Nucleic acid chemistry and DNA repair

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Evangelos Moudrianakis
Professor, Biology
Chromatin structure and function

Ostermeier scientific imageMarc Ostermeier
Professor, Chemical & Biomolecular Engineering
Biomolecular engineering
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Sean Prigge
Associate Professor, Molecular Microbiology & Immunology
Crystallography of malaria proteins

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Elijah Roberts
Assistant Professor, Biophysics
Investigating the creation and use of in silico cell models

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Steven Rokita
Professor, Chemistry
Mechanistic and structural studies of enzymes, reversible but covalent reactivity of nucleic acids

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Justine Roth
Associate Professor, Chemistry
Metalloenzyme catalysis, mechanistic studies of oxidative protein modifiction and damage by reactive oxygen species

Sadegh-Nasseri scientific image

Scheherazade Sadegh-Nasseri
Associate Professor, Pathology
Mechanisms of T cell activation and unresponsiveness, mechanisms of antigen processing and presentation

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Joel Schildbach
Professor, Biology
Structural, biochemical, and functional studies of proteins involved in DNA transfer by bacterial conjugation

Schleif scientific imageRobert Schleif
Professor, Biology
Mechanism of protein function, particularly regulatory proteins, using genetic, biochemical, biophysical, and computational methods
Shortle scientific imageDavid Shortle
Professor, Biological Chemistry
Protein folding and stability, NMR analysis of denatured protein, prediction of protein structure from sequence
Jungsan Sohn research image

Jungsan Sohn
Assistant Professor, Biophysics & Biophysical Chemistry
Structure and function of biological stress-sensors

Stivers scientific imageJim Stivers
Professor, Pharmacology & Molecular Sciences
Enzymology of DNA repair and topoisomerases, structure and mechanism by NMR spectroscopy, inhibitor design
Tolman scientific imageJoel Tolman
Associate Professor, Chemistry
Experimental and theoretical NMR, protein structure and function, polyubiquitylation
Townsend scientific imageCraig Townsend
Professor, Chemistry
Natural product chemistry, enzymology and molecular biology, fatty acid synthase inhibitors for cancer, tuberculosis and obesity
Wade scientific imageHerschel Wade
Assistant Professor, Biophysics & Biophysical Chemistry
Molecular mechanisms of ligand-dependent transcriptional activation-repression, broadly-specific receptor-ligand systems
Wolberger scientific imageCynthia Wolberger
Professor, Biophysics & Biophysical Chemistry
Structural and mechanistic studies of transcription regulation and ubiquitin signaling
Woodson scientific imageSarah Woodson
Professor, Biophysics
Folding and dynamics of RNA and RNA-protein complexes
Woolf scientific imageTom Woolf
Professor, Physiology
Computational biophysics of membrane systems, membrane proteins, and protein:lipid interactions; development of new methods for relative free energy and conformational transitions, computational analysis of ligand binding
Xiao scientific imageJie Xiao
Assistant Professor, Biophysics & Biophysical Chemistry
Molecular mechanisms of transcription and cytokinesis in bacterial cells
Zhang scientific imageJin Zhang
Associate Professor, Pharmacology & Molecular Sciences
Spatiotemporal regulation of signal transduction

Program in Molecular Biophysics
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