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Protein Folding & Dynamics

Amzel scientific imageMario Amzel
Structure and mechanism of proteins involved in redox or phosphoryl transfer reactions, such as FPPS, MICAL, and Pl3K-alpha.  Many of these proteins studied are targets for drug design.
Barrick scientific imageDoug Barrick
Stability and folding of modular proteins, structure and sequence analysis of protein evolution, protein-protein interactions in signaling pathways
Fleming scientific image

Karen Fleming
Membrane protein folding, cellular biogenesis of membrane proteins, thermodynamics of protein-protein interactions in membranes, protein engineering, membrane protein modeling

Dominique Frueh research imageDominique Frueh
Assistant Professor
NMR studies of modulations of protein dynamics and conformations in active enzymatic systems
Garcia-Moreno scientific imageBertrand García-Moreno
Experimental and computational studies of protein electrostatics, structure-based energy calculations, ligand-driven conformational transition, bioenergetics
Hilser scientific imageVincent J. Hilser
Conformational fluctuations in function, disease and evolution
Kaiser research imageChristian Kaiser
Assistant Professor
Single-molecule studies of the machines and processes in protein translation, translocation and folding
Lecomte scientific imageJuliette Lecomte
Structure and dynamics of protein in solution by NMR spectroscopy
Sadegh-Nasseri research imageScheherazade Sadegh-Nasseri
Mechanisms of T cell activation and unresponsiveness, mechanisms of antigen processing and presentation
Shortle scientific imageDavid Shortle
Protein folding and stability, NMR analysis of denatured protein, preduction of protein structure from sequence


Program in Molecular Biophysics
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3400 N. Charles Street
Baltimore, MD 21218

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410-516-5199 fax


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